Publications (Page 2)

Prolonged Circulating Lipid Nanoparticles Enabled by High-Density Gd-DTPA-Bis(stearylamide) for Long-Lasting Enhanced Tumor Magnetic Resonance Imaging

Margalik DA, Chen J, Ho T, Ding L, Dhaliwal A, Doria AS, Zheng G Bioconjugate Chemistry DOI: 10.1021/acs.bioconjchem.2c00445 Porphysomes (PS) were explored to incorporate different types of diethylenetriaminepentaacetic-acid-gadolinium-(III) (Gd-DTPA)-lipids into their bilayer membrane to assess PS potential as an MRI contrast agent. The Gd-dPS-BSA by integration of over 30% Gd-DTPA-bis(stearylamide)Continue Reading

Photodynamic Therapy for Colorectal Cancer: A Systematic Review of Clinical Research

Guidolin K, Ding L, Yan H, Englesakis M, Chadi S, Quereshy F, Zheng G Surgical Innovation DOI: 10.1177/15533506221083545 Photodynamic therapy (PDT) is a therapeutic modality that can be used to ablate tumors using the localized generation of reactive oxygen species by combining a photosensitizer, light, and molecular oxygen. This modalityContinue Reading

Measurement of intact and dissociated porphyrin-lipid nanoparticle concentration in tissue using diffuse reflectance and fluorescence spectroscopy

Husby T, Valic M, Zheng G, Wilson BC, Weersink R SPIE BiOS DOI: 10.1117/12.2609870 We present ongoing work to develop and verify a measurement technology using diffuse reflectance spectroscopy and fluorescence spectroscopy to measure in-vivo concentrations of intact and dissociated porphysomes. Porphysomes (PS) are multifunctional liposome-like nanoparticles composed of porphyrin-lipidContinue Reading

Targeted Theranostic 111In/Lu-Nanotexaphyrin for SPECT Imaging and Photodynamic Therapy

Cheng M, Overchuk M, Rajora MA, Lou JWH, Chen W, Pomper MG, Chen J, Zheng G ACS Molecular Pharmaceutics DOI: 10.1021/acs.molpharmaceut.1c00819 Theranostic nanoparticles aim to integrate diagnostic imaging and therapy to facilitate image-guided treatment protocols. Herein, we present a theranostic nanotexaphyrin for prostate-specific membrane antigen (PSMA)-targeted radionuclide imaging and focalContinue Reading

Nanomedicine in Hepatocellular Carcinoma: A New Frontier in Targeted Cancer Treatment

Bakrania A, Zheng G, Bhat M Pharmaceutics DOI: 10.3390/pharmaceutics14010041 Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death and is associated with a dismal median survival of 2–9 months. The fundamental limitations and ineffectiveness of current HCC treatments have led to the development of a vast range ofContinue Reading

Synthesis and Characterization of Multi-Modal Phase-Change Porphyrin Droplets

Yoo K, Dhaliwal A, Chen J, Sheeran PS, Zheng G JoVE (Journal of Visualized Experiments) DOI: 10.3791/62665 Phase-change droplets are a class of ultrasound contrast agents that can convert into echogenic microbubbles in situ with the application of sufficient acoustic energy. Droplets are smaller and more stable than their microbubble counterparts. However,Continue Reading

Repeated porphyrin lipoprotein-based photodynamic therapy controls distant disease in mouse mesothelioma via the abscopal effect

Lou J, Aragaki M, Bernards N, Kinoshita T, Mo J, Motooka Y, Ishiwata T, Gregor A, Chee T, Chen Z, Chen J, Kaga K, Wakasa S, Zheng G, Yasufuku K Nanophotonics DOI: 10.1515/nanoph-2021-0220 While photodynamic therapy (PDT) can induce acute inflammation in the irradiated tumor site, a sustained systemic, adaptiveContinue Reading

Porphyrin-lipid nanovesicles (Porphysomes) are effective photosensitizers for photodynamic therapy

Guidolin K, Ding L, Chen J, Wilson BC, Zheng G Nanophotonics DOI: 10.1515/nanoph-2021-0220 Porphysomes (PS) are liposome-like nanoparticles comprising pyropheophorbide-conjugated phospholipids that have demonstrated potential as multimodal theranostic agents for applications that include phototherapies, targeted drug delivery and in vivo fluorescence, photoacoustic, magnetic resonance or positron emission imaging. Previous therapeutic applications focusedContinue Reading

Porphyrin-lipid stabilized paclitaxel nanoemulsion for combined photodynamic therapy and chemotherapy

Chang E, Bu J, Ding L, Lou JWH, Valic MS, Cheng MHY, Rosilio V, Chen J, Zheng G Journal of Nanobiotechnology DOI: 10.1186/s12951-021-00898-1 Porphyrin-lipids are versatile building blocks that enable cancer theranostics and have been applied to create several multimodal nanoparticle platforms, including liposome-like porphysome (aqueous-core), porphyrin nanodroplet (liquefied gas-core),Continue Reading

Fast, facile, base-free microwave-assisted metallation of bacteriochlorophylls and corresponding high yield synthesis of TOOKAD

Cheng MHY, Cevallos A, Rajora MA, Zheng G Journal of Porphyrins and Pthalocyanines, 2021 DOI: 10.1142/S1088424621500656 Naturally-derived metallo-bacteriochlorophylls have attracted much attention since their clinical approval for cancer photodynamic therapy. Their therapeutic properties are rooted in the metal complexation of bacteriochlorophylls, which endows them with optical properties favourable for biophotonicContinue Reading