Kassab G, Doran K, Mo Y, Zheng G Nano Letters DOI: 10.1021/acs.nanolett.3c03547 Lung-targeting RNA-carrying lipid nanoparticles (LNPs) are often intravenously administered and accumulate in the pulmonary endothelium. However, most respiratory diseases are localized in the airway or the alveolar epithelium. Inhalation has been explored as a more direct delivery method,Continue Reading
Cheng MHY, Mo Y, Zheng G Advanced Healthcare Materials, 2020 DOI: 10.1002/adhm.202001549 Hypoxia is a ubiquitous feature of solid tumors, which plays a key role in tumor angiogenesis and resistance development. Conventional hypoxia detection methods lack continuous functional detection and are generally less suitable for dynamic hypoxia measurement. Optical sensorsContinue Reading
Valic MS, Hamlin M, Schimmer P & Zheng GJournal of Controlled ReleaseDOI:10.1016/j.jconrel.2020.04.002 A shared feature in the value proposition of every nanomaterial-based drug delivery systems is the desirable improvement in the disposition (or ADME) and pharmacokinetic profiles of the encapsulated drug being delivered. Remarkable progress has been made towards understandingContinue Reading
Choi V, Rajora MA & Zheng GBioconjugate Chemistry, 2020DOI:10.1021/acs.bioconjchem.0c00029 Sonodynamic therapy (SDT) is a promising therapeutic platform for minimally invasive cancer treatment in which acoustically susceptible drug agents, sonosensitizers, are activated by deep-tissue-penetrating low frequency ultrasound. Despite growing research in recent years, the field has yet to clearly elucidate broadlyContinue Reading
Guidolin K & Zheng GACS Nano, 2019DOI:10.1021/acsnano.9b08659 Nanomedicines have historically struggled to find clinical relevance and to achieve translation successfully. In this Perspective, we discuss possible reasons for this difficulty and highlight several key features of nanomedicines that are often overlooked by biomedical engineers. We present the notion of clinicalContinue Reading
Keca JM, Zheng G Coordination Chemistry Reviews, 2019 DOI: 10.1016/j.ccr.2017.08.026 In the present review, we present the history and future of texaphyrins, pentaaza Schiff base macrocycles with an expanded 5-coordination sphere, possessing chelation prowess of 24 different stable 1:1 complexes. Intrinsically unique photophysical and magnetic properties of metallotexaphyrins have enabledContinue Reading
Dhaliwal A, Zheng G Theranostics, 2019 DOI:10.7150/thno.37204 The enhanced permeability and retention (EPR) effect has underlain the predominant nanomedicine design philosophy for the past three decades. However, growing evidence suggests that it is over-represented in preclinical models, and agents designed solely using its principle of passive accumulation can only beContinue Reading
Valic MS & Zheng G Theranostics, 2019 DOI: 10.7150/thno.34509 A critical step in the translational science of nanomaterials from preclinical animal studies to humans is the comprehensive investigation of their disposition (or ADME) and pharmacokinetic behaviours. Disposition and pharmacokinetic data are ideally collected in different animal species (rodent and nonrodent),Continue Reading
Harmatys KM, Overchuk M & Zheng G Accounts of Chemical Research, 2019 DOI: 10.1021/acs.accounts.9b00104 The sun is the most abundant source of energy on earth. Phototrophs have discovered clever strategies to harvest this light energy and convert it to chemical energy for biomass production. This is achieved in light-harvesting complexes,Continue Reading
Lou J, Zhang L & Zheng G Advanced Therapeutics, 2019 DOI: 10.1002/adtp.201800128 Cancer immunotherapies can elicit long term, durable responses in only a fraction of patients. As such, there is a need to increase the number of patients who can benefit from cancer immunotherapies. By virtue of their versatility andContinue Reading
