2023
- Nanostructure-Driven Indocyanine Green Dimerization Generates Ultra-Stable Phototheranostics Nanoparticles
- Protease-Activatable Porphyrin Molecular Beacon for Osteoarthritis Management
- Light-Activated siRNA Endosomal Release (LASER) by Porphyrin Lipid Nanoparticles
- Novel Strategy to Drive the Intracellular Uptake of Lipid Nanoparticles for Photodynamic Therapy
- Development of a Clinically Viable Strategy for Nanoparticle-Based Photodynamic Therapy of Colorectal Cancer
- Repeated photodynamic therapy mediates the abscopal effect through multiple innate and adaptive immune responses with and without immune checkpoint therapy
2022
- Self-Organization of Lipid-Porphyrin Conjugates at the Air/Water Interface
- Repeated photodynamic therapy mediates the abscopal effect through multiple innate and adaptive immune responses with and without immune checkpoint therapy
- Porphyrin nanoemulsion for antimicrobial photodynamic therapy: effective delivery to inactivate biofilm-related infections
- Prolonged Circulating Lipid Nanoparticles Enabled by High-Density Gd-DTPA-Bis(stearylamide) for Long-Lasting Enhanced Tumor Magnetic Resonance Imaging
- Photodynamic Therapy for Colorectal Cancer: A Systematic Review of Clinical Research
- Measurement of intact and dissociated porphyrin-lipid nanoparticle concentration in tissue using diffuse reflectance and fluorescence spectroscopy
- Nanomedicine in Hepatocellular Carcinoma: A New Frontier in Targeted Cancer Treatment
2021
- Targeted Theranostic 111In/Lu-Nanotexaphyrin for SPECT Imaging and Photodynamic Therapy
- Synthesis and Characterization of Multi-Modal Phase-Change Porphyrin Droplets
- Repeated porphyrin lipoprotein-based photodynamic therapy controls distant disease in mouse mesothelioma via the abscopal effect
- Porphyrin-lipid nanovesicles (Porphysomes) are effective photosensitizers for photodynamic therapy
- Porphyrin-lipid stabilized paclitaxel nanoemulsion for combined photodynamic therapy and chemotherapy
- Fast, facile, base-free microwave-assisted metallation of bacteriochlorophylls and corresponding high yield synthesis of TOOKAD
- High Frequency Array-Based Nanobubble Nonlinear Imaging in a Phantom and In Vivo
2020
- Subtherapeutic Photodynamic Treatment Facilitates Tumor Nanomedicine Delivery and Overcomes Desmoplasia
- Nano versus Molecular: Optical Imaging Approaches to Detect and Monitor Tumor Hypoxia
- Lipoprotein‐Like Nanoparticle Carrying Small Interfering RNA Against Spalt‐Like Transcription Factor 4 Effectively Targets Hepatocellular Carcinoma Cells and Decreases Tumor Burden
- Concurrent visual and acoustic tracking of passive and active delivery of nanobubbles to tumors
- High frequency ultrasound nonlinear scattering from porphyrin nanobubbles
- Simultaneous intravital optical and acoustic monitoring of ultrasound-triggered nanobubble generation and extravasation
- Photophysics of J-aggregating porphyrin-lipid photosensitizers in liposomes: Impact of lipid saturation
- Guidelines for the experimental design of pharmacokinetic studies with nanomaterials in preclinical animal models
- Activating drugs with sound: Mechanisms behind sonodynamic therapy and the role of nanomedicine
2019
- Photodynamic therapy enables tumor-specific ablation in preclinical models of thyroid cancer
- Long‐circulating prostate‐specific membrane antigen‐targeted NIR phototheranostic agent
- Nanomedicines lost in translation
- An orthotopic endometrial cancer model with retroperitoneal lymphadenopathy made from in vivo propagated and cultured VX2 cells
- Texaphyrin: From molecule to nanoparticle
- An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells
- Improving accessibility of EPR-insensitive tumor phenotypes using EPR-adaptive strategies: Designing a new perspective in nanomedicine delivery
- Nanoemulsion with porphyrin shell for cancer theranostics
- Stable J‐aggregation of an aza‐BODIPY‐lipid in a liposome for optical cancer imaging
- pH driven self-assembly of aza-BODIPY J-aggregates
- Research tools for extrapolating the disposition and pharmacokinetics of nanomaterials from preclinical animals to humans
- Rational design of photosynthesis-inspired nanomedicines
- Use of porphysomes to detect primary tumour, lymph node metastases, intra-abdominal metastases and as a tool for image-guided lymphadenectomy: Proof of concept in endometrial cancer
- Tailoring porphyrin conjugation for nanoassembly-driven phototheranostic properties
- Advancing cancer immunotherapies with nanotechnology
2018
- Tuning pharmacokinetics to improve tumor accumulation of a prostate-specific membrane antigen-targeted phototheranostic agent
- Threshold-dependent nonlinear scattering from porphyrin nanobubbles for vascular and extravascular applications
- Mixed and matched metallo-nanotexaphyrin for customizable biomedical imaging
- Advanced photosensitizer activation strategies for smarter photodynamic therapy beacons
- Multi‐pronged biomimetic approach to create optically tunable nanoparticles
- Nanomedicine development guided by FRET imaging
2017
- Breaking free from vascular confinement: status and prospects for submicron ultrasound contrast agents
- Advancing porphyrin's biomedical utility via supramolecular chemistry
- Overcoming obstacles in the tumor microenvironment: Recent advancements in nanoparticle delivery for cancer theranostics
- Molecular imaging in drug development: update and challenges for radiolabeled antibodies and nanotechnology
- In Vivo Potential of Manganese Chelated Porphysomes as MRI Contrast Agents
- Specific, direct amplified microRNA detection with microRNA:Argonaute-2 cleavage (miRACle) beacons
- Molecular imaging in drug development: Update and challenges for radiolabeled antibodies and nanotechnology
- Tailored theranostic apolipoprotein E3 porphyrin-lipid nanoparticles target glioblastoma
2016
- Targeting SR-BI for cancer diagnostics, imaging and therapy
- Activatable fluorescence: From small molecule to nanoparticle
- Porphysome nanoparticles for enhanced photothermal therapy in a patient-derived orthotopic pancreas xenograft cancer model: A pilot study
- Controlling spatial heat and light distribution by using photothermal enhancing auto-regulated liposomes (PEARLs)
- Nanoparticle-enabled selective destruction of prostate tumor using MRI-guided focal photothermal therapy
- Nanotexaphyrin: One-pot synthesis of a manganese texaphyrin-phospholipid nanoparticle for magnetic resonance imaging
- Chlorosome-inspired synthesis of templated metallochlorin-lipid nanoassemblies for biomedical applications
- Multimodal micro, nano, and size conversion ultrasound agents for imaging and therapy
- Nanostructure-dependent ratiometric NIR fluorescence enabled by ordered dye aggregation
- Topical MMP beacon enabled fluorescence-guided resection of oral carcinoma
- Matrix metalloproteinase-based photodynamic molecular beacons for targeted destruction of bone metastases in vivo
- Stable J-aggregation enabled dual photoacoustic and fluorescence nanoparticles for intraoperative cancer imaging
2015
- Organized aggregation of porphyrins in lipid bilayers for third harmonic generation microscopy
- Multimodal image-guided surgical and photodynamic interventions in head-and-neck cancer: From primary tumor to metastatic drainage
- Nano-enabled SERS reporting photosensitizers
- Learning from Biology: Synthetic Lipoproteins for Drug Delivery
- Phototheranostic porphyrin nanoparticles enable visualization and targeted treatment of head and neck cancer in clinically relevant models
- Multimodal nanoparticle for primary tumor delineation and lymphatic metastasis mapping in a head-and-neck cancer rabbit model
- Theranostic lipid nanoparticles for cancer medicine
- Molecular interactions in organic nanoparticles for phototheranostic applications
- A PEGylation-free biomimetic porphyrin nanoplatform for personalized cancer theranostics
- In situ conversion of porphyrin microbubbles to nanoparticles for multimodality imaging
- Self-sensing porphysomes for fluorescence-guided photothermal therapy
- Activation kinetics of zipper molecular beacons
2014
- Learning from biology: Synthetic lipoproteins for drug delivery
- Synthesis and characterization of a new natural product analog, 132-173-bacteriochlorophyllone a
- Lipid-based nanoparticles in the systemic delivery of siRNA
- Modulation of reactive oxygen species photogeneration of bacteriopheophorbide a derivatives by exocyclic E-ring opening and charge modifications
- Porphysome nanoparticles: Tailoring treatments with nature’s pigments
- Stimuli-responsive photoacoustic nanoswitch for in vivo sensing applications
- An MRI-sensitive, non-photobleachable porphysome photothermal agent
- Nanoparticle-enabled, image-guided treatment planning of target specific RNAi therapeutics in an orthotopic prostate cancer model
- Porphysome nanotechnology: A paradigm shift in lipid-based supramolecular structures
- Aggregate enhanced trimodal porphyrin shell microbubbles for ultrasound, photoacoustic and fluorescence imaging
- Optically controlled pore formation in self-sealing giant porphyrin vesicles
- Organic biophotonic nanoparticles: Porphysomes and beyond
2013
- Reactive oxygen species photogeneration of bacteriopheophorbide a derivatives by exocyclic E-ring opening and charge modifications
- Near-infrared fluorescent imaging of metastatic ovarian cancer using folate receptor-targeted high-density lipoprotein nanocarriers
- Biologically-targeted detection of primary and micro-metastatic ovarian cancer
- One minute, sub-one-watt photothermal tumor ablation using porphysomes, intrinsic multifunctional nanovesicles
- Imaging the cytosolic drug delivery mechanism of HDL-like nanoparticles
- Inherently multimodal nanoparticle-driven tracking and real-time delineation of orthotopic prostate tumors and micrometastases
- Self-assembled porphyrin nanodiscs with structure-dependent activation for phototherapy and photodiagnostic applications
- Engineering multifunctional nanoparticles: All-in-one versus one-for-all
- Ablation of hypoxic tumors with dose-equivalent photothermal, but not photodynamic, therapy using a nanostructured porphyrin assembly
2012
- Efficient systemic delivery of siRNA by using high-density lipoprotein-mimicking peptide lipid nanoparticles
- Intrinsically copper-64-labeled organic nanoparticles as radiotracers
- Synthesis and Development of Lipoprotein‐Based Nanocarriers for Light‐Activated Theranostics
- Porphyrin-lipid stabilized gold nanoparticles for surface enhanced Raman scattering based imaging
- Flexible or fixed: a comparative review of linear and cyclic cancer-targeting peptides
- Porphyrin shell microbubbles with intrinsic ultrasound and photoacoustic properties
- Conformational modulation of in vitro activity of cyclic RGD peptides via aziridine aldehyde-driven macrocyclization chemistry
- Enzymatic regioselection for the synthesis and biodegradation of porphysome nanovesicles
2011
- Mechanistic insights into LDL nanoparticle-mediated siRNA delivery
- In vivo detection of phospholipase C by enzyme-activated near-infrared probes
- Porphyrin FRET acceptors for apoptosis induction and monitoring
- Liposomal nanostructures for photosensitizer delivery
- Porphyrin-crosslinked-hydrogel for fluorescence-guided monitoring and surgical resection
- Attenuation of nontargeted cell-kill using a high-density lipoprotein-mimicking peptide-phospholipid nanoscaffold
- Imaging of specific activation of photodynamic molecular beacons in breast cancer vertebral metastases
- Lipoprotein-inspired nanoparticles for cancer theranostics
- Evaluation of bacteriochlorophyll-reconstituted low-density lipoprotein nanoparticles for photodynamic therapy efficacy in vivo
- Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents
- Cytosolic delivery of LDL nanoparticle cargo using photochemical internalization
- Efficient cytosolic delivery of siRNA using HDL-mimicking nanoparticles
- Transforming a targeted porphyrin theranostic agent into a PET imaging probe for cancer
- Multimodal bacteriochlorophyll theranostic agent
2010
- Investigating the specific uptake of EGF-conjugated nanoparticles in lung cancer cells using fluorescence imaging
- Facile synthesis of Raman active phospholipid gold nanoparticles
- In vitro assessment of poly-iodinated triglyceride reconstituted low-density lipoprotein: Initial steps toward CT molecular imaging
- Programmed nanoparticle aggregation using molecular beacons
- Facile synthesis of advanced photodynamic molecular beacon architectures
- Peptide-based molecular beacons for cancer imaging and therapy
- Activatable photosensitizers for imaging and therapy
- HDL-mimicking peptide-lipid nanoparticles with improved tumor targeting
2009
- Biomimetic nanocarrier for direct cytosolic drug delivery
- Synthesis and evaluation of a stable bacteriochlorophyll-analog and its incorporation into high-density lipoprotein nanoparticles for tumor imaging
- "Zipper" molecular beacons: A generalized strategy to optimize the performance of activatable protease probes
- FRET quenching of photosensitizer singlet oxygen generation
- Photodynamic molecular beacon triggered by fibroblast activation protein on cancer-associated fibroblasts for diagnosis and treatment of epithelial cancers
2008
- Lipoprotein nanoplatform for targeted delivery of diagnostic and therapeutic agents
- A tumor mRNA-triggered photodynamic molecular beacon based on oligonucleotide hairpin control of singlet oxygen production
- Activatable smart probes for molecular optical imaging and therapy
2007
- Naphthalocyanine-reconstituted LDL nanoparticles for in vivo cancer imaging and treatment
- Enhanced cancer-targeted delivery using engineered high-density lipoprotein-based nanocarriers
- Using the singlet oxygen scavenging property of carotenoid in photodynamic molecular beacons to minimize photodamage to non-targeted cells
- Mimicking nature's nanocarrier: Synthetic low-density lipoprotein-like nanoparticles for cancer-drug delivery
- Using molecular beacons for cancer imaging and treatment
- Ligand conjugated low-density lipoprotein nanoparticles for enhanced optical cancer imaging in vivo
- Photodynamic molecular beacon as an activatable photosensitizer based on protease-controlled singlet oxygen quenching and activation
- Peptide-based pharmacomodulation of a cancer-targeted optical imaging and photodynamic therapy agent
- Killer beacons for combined cancer imaging and therapy
2006
- Targeted photodynamic therapy agent with a built-in apoptosis sensor for in vivo near-infrared imaging of tumor apoptosis triggered by its photosensitization in situ
- Low-density lipoprotein nanoparticles as magnetic resonance imaging contrast agents
- Photodynamic therapy agent with a built-in apoptosis sensor for evaluating its own therapeutic outcome in situ
2005
- Rerouting lipoprotein nanoparticles to selected alternate receptors for the targeted delivery of cancer diagnostic and therapeutic agents
- High payload delivery of optical imaging and photodynamic therapy agents to tumors using phthalocyanine-reconstituted low-density lipoprotein nanoparticles
- Near-infrared optical imaging of B16 melanoma cells via low-density lipoprotein-mediated uptake and delivery of high emission dipole strength tris[(porphinato)zinc(II)] fluorophores
2004
- Metabolic imaging of tumors using intrinsic and extrinsic fluorescent markers
- Protease-triggered photosensitizing beacon based on singlet oxygen quenching and activation
- Redox ratio of mitochondria as an indicator for the response of photodynamic therapy
- Carbocyanine labeled LDL for optical imaging of tumors
2003
- Metabolism-enhanced tumor localization by fluorescence imaging: in vivo animal studies
- Pyropheophorbide 2-deoxyglucosamide: a new photosensitizer targeting glucose transporters
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